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30 Jan 2014 Page 1 . Medicago specialized metabolites, we refer to previous reviews on Medicago and . be part of the sugar chains of Medicago saponins.22 To date catula two MATE-type transporters, MATE1 and MATE2, have.

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Because this is a transporter-mediated process, cationic drug clearance may be This review examines the clearance of cardiovascular drugs by the OCT system. . Only a single study to date links a class III antiarrhythmic drug, sotalol, . toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of 

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18 Dec 2015 apical transporters responsible for uric acid reabsorption in the kidney. electronically and this page is the manifestation of the electronic SUBJECT: Addendum to NDA 209788 Nonclinical Review dated September 3, 2015 RDEA594 inhibition of the transport proteins BCRP, MATE1, MATE2K, and 

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REVIEW nature publishing group. Intracellular drug concentrations are fundamentally important unbound concentration at the site of metabolism or transport. In addition .. Mate1−/− mice. NA. ↔ . To date, many of these techniques are.

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