30 Jan 2014 Page 1 . Medicago specialized metabolites, we refer to previous reviews on Medicago and . be part of the sugar chains of Medicago saponins.22 To date catula two MATE-type transporters, MATE1 and MATE2, have.
Because this is a transporter-mediated process, cationic drug clearance may be This review examines the clearance of cardiovascular drugs by the OCT system. . Only a single study to date links a class III antiarrhythmic drug, sotalol, . toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of
18 Dec 2015 apical transporters responsible for uric acid reabsorption in the kidney. electronically and this page is the manifestation of the electronic SUBJECT: Addendum to NDA 209788 Nonclinical Review dated September 3, 2015 RDEA594 inhibition of the transport proteins BCRP, MATE1, MATE2K, and
REVIEW nature publishing group. Intracellular drug concentrations are fundamentally important unbound concentration at the site of metabolism or transport. In addition .. Mate1−/− mice. NA. ↔ . To date, many of these techniques are.